Perinatal Factors Influencing Hepatic Glucose-6-Phosphatase Enzyme Activity
نویسندگان
چکیده
منابع مشابه
Studies on carbohydrate metabolism in rat liver slices. VI. Hormonal factors influencing glucose-6-phosphatase.
In any consideration of carbohydrate metabolism of the liver, glucose-6phosphate plays an important r81e. Glucose must first be phosphorylated to glucose-6-phosphate in order to enter the glycolytic pathway to form glycogen and fat for storage, or to be burned for energy. On the other hand, liver phosphatase must split glucose-6-phosphate into glucose and inorganic phosphate before stored carbo...
متن کاملThe ontogeny of human hepatic microsomal glucose-6-phosphatase proteins.
We have studied 250 human liver biopsy samples to determine the ontogeny of the microsomal glucose-6-phosphatase (EC 3.1.3.9) system. Human hepatic glucose-6-phosphatase enzyme activity develops at 11 weeks' gestation and slowly increases to approximately 10% of adult activity at term. In the first week after birth, activity rises to adult values. Increases in enzyme activity coincide with incr...
متن کاملMicrosomal Membrane Permeability and the Hepatic Glucose-6-phosphatase System
We have proposed that glucose-6.phosphatase (EC 3.1.3.9) is a two-component system consisting of (a) a glucose-6-P-specific transporter which mediates the movement of the hexose phosphate from the cytosol to the lumen of the endoplasmic reticulum (or cisternae of the isolated microsomal vesicle), and (b) a nonspecific phosphohydrolase-phosphotransferase localized on the luminal surface of the m...
متن کاملThe microsomal glucose-6-phosphatase enzyme of pancreatic islets.
Microsomal fractions isolated from pancreatic islet cells were shown to contain high specific glucose-6-phosphatase activity. The islet-cell glucose-6-phosphatase enzyme has the same Mr (36,500), similar immunological properties and kinetic characteristics to the hepatic microsomal glucose-6-phosphatase enzyme.
متن کاملStabilization of glucose-6-phosphatase activity by a 21 000-dalton hepatic microsomal protein.
Hepatic microsomal glucose-6-phosphatase activity was rendered extremely unstable by a variety of techniques: (a) incubation at pH 5.0; (b) extraction of the microsomal fraction in the presence of 1% Lubrol; (c) various purification procedures. These techniques all result in the removal of a 21 kDa polypeptide from the fraction containing glucose-6-phosphatase activity. The 21 kDa protein was p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Perinatology
سال: 2000
ISSN: 0743-8346,1476-5543
DOI: 10.1038/sj.jp.7200379